These are Heroes that have used the Hero Booster Program and have turned insane as a result. Most likely they are low-ranking heroes who were jealous of IS-KA's sudden rise through the ranks and stealing their thunders. They were later stopped, (with the exception of Mr. Big Horn), when Crea and her grandfather were able to transmit the antidote to the Hero Booster Program through their smartphones. It is very likely that those who participated in the chaos had either been lowered in rank or had their Hero's Licenses revoked.

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